HCID 20520810, compound → HCID 20520782, compound

HRID 223825Notes

Reaction equation

C(OC(CNC(=O)COC1C=C2C(C3C(CC)(C2)CCC(=O)C=3)=C(Cl)C=1Cl)=O)(C)(C)C.C([O:36][C:37]([CH2:39][CH2:40][NH:41][C:42](=[O:63])[CH2:43][O:44][C:45]1[CH:57]=[C:56]2[C:48]([C:49]3[C:54]([CH2:58][CH3:59])([CH2:55]2)[CH2:53][CH2:52][C:51](=[O:60])[CH:50]=3)=[C:47]([Cl:61])[C:46]=1[Cl:62])=[O:38])(C)(C)C>>[C:37]([CH2:39][CH2:40][NH:41][C:42](=[O:63])[CH2:43][O:44][C:45]1[CH:57]=[C:56]2[C:48]([C:49]3[C:54]([CH2:58][CH3:59])([CH2:55]2)[CH2:53][CH2:52][C:51](=[O:60])[CH:50]=3)=[C:47]([Cl:61])[C:46]=1[Cl:62])([OH:38])=[O:36]

Participants

Reactant 2

HCID 20520810HCID 20520810, compound

HCID 20520811HCID 20520811, compound

Product 1

HCID 20520782HCID 20520782, compound

Procedure

By carrying out the reaction as described in Example 107, Step B, except that the N-(t-butoxycarbonylmethyl)-[(5,6-dichloro-9a-ethyl-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]acetamide is replaced by an equimolar amount of N-[2-(t-butoxycarbonyl)ethyl]-[(5,6-dichloro-9a-ethyl-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]acetamide. There is obtained N-(2-carboxyethyl)-[(5,6-dichloro-9a-ethyl-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]acetamide.

Workup

customthe reaction

Sources & evidence

ORD record: ord-c36046484fbc4fb3b0753d05e65df66a
Source dataset: uspto-grants-1982_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04356314

Reaction notes

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