Ammonia → 1-(Chloromethyl)-5-nitro-1,2-dihydro-3h-benzo[e]indole-8-carbonitrile

HRID 2238426Notes

Reaction equation

HRID 2238426 reaction equation
[Cl:1][CH2:2][CH:3]1[C:11]2[C:10]3[CH:12]=[C:13]([C:16]#[N:17])[CH:14]=[CH:15][C:9]=3[CH:8]=[CH:7][C:6]=2[N:5](C(OC(C)(C)C)=O)[CH2:4]1.O1CCOCC1.[N+:31]([O-])([O-:33])=[O:32].[K+].N>Cl.OS(O)(=O)=O>[Cl:1][CH2:2][CH:3]1[C:11]2[C:10]3[CH:12]=[C:13]([C:16]#[N:17])[CH:14]=[CH:15][C:9]=3[C:8]([N+:31]([O-:33])=[O:32])=[CH:7][C:6]=2[NH:5][CH2:4]1

Participants

7

Reactant 4

HCID 222AmmoniaHCID 24434Potassium NitrateHCID 312751,4-DioxaneHCID 44550496tert-butyl 1-(chloromethyl)-8-cyano-1,2-dihydro-3H-benzo[e]indole-3-carboxylate

Product 1

HCID 445494061-(Chloromethyl)-5-nitro-1,2-dihydro-3h-benzo[e]indole-8-carbonitrileYield 72%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 1118Sulfuric AcidSolvent2×

Conditions

Temperature
0 °C

Procedure

A solution of 196 (30 mg, 0.088 mmol) in HCl(g) saturated dioxane (3 mL) was stirred for 1 h. The solvent was evaporated to provide the crude amine hydrochloride (24 mg, 100%). This solid was cooled to 0° C. and treated with conc. H2SO4 (2 mL). A cooled (O OC) solution of KNO3 (9 mg, 0.088 mmol) in conc. H2SO4 (0.5 mL) was then added dropwise. After 15 min, the mixture was poured into ice water and conc. aqueous ammonia was carefully added until the pH of the mixture was 3-4. Solid KHCO3 was then carefully added until the pH of the mixture was 8. The mixture was partitioned between CH2Cl2 and water, and the aqueous layer was extracted with CH2Cl2 (×3). The combined organic extracts were washed with brine and dried. The CH2Cl2 was removed under reduced pressure and the residue was triturated with MeOH to give 1-(chloromethyl)-5-nitro-1,2-dihydro-3H-benzo[e]indole-8-carbonitrile (197) (18 mg, 72%) as red crystals: mp 231-234° C.; 1H NMR [(CD3)2SO] δ 8.54 (dd, J=1.5, 0.5 Hz, 1 H), 8.22 (dd, J=9.0, 0.4 Hz, 1H), 7.80 (s, 1H), 7.59 (dd, J=9.0, 1.6 Hz, 1H), 6.63 (d, J=1.3 Hz, 1H), 4.32-4.23 (m, 1H), 3.95 (dd, J=11.0, 3.8 Hz, 1H), 3.84 (td, J=10.3, 2.3 Hz, 1H), 3.79-3.70 (m, 2H); 13C NMR δ 151.8, 148.1, 130.6, 129.9, 126.8, 125.7, 125.0, 120.0, 119.6, 112.8, 111.4, 51.8, 47.5, 43.5. Anal. (C14H10ClN3O2) C, H, N.

Workup

  1. customThe solvent was evaporated
  2. customto provide the crude amine hydrochloride (24 mg, 100%)
  3. additionwas then added dropwise
  4. additionwas carefully added until the pH of the mixture
  5. customThe mixture was partitioned between CH2Cl2 and water
  6. extractionthe aqueous layer was extracted with CH2Cl2 (×3)
  7. washThe combined organic extracts were washed with brine
  8. customdried
  9. customThe CH2Cl2 was removed under reduced pressure
  10. customthe residue was triturated with MeOH

Sources & evidence

ORD record
ord-93d680d0a4784f46a65271669605cc44
Source dataset
uspto-grants-2010_05
Patent number
US07718688B2

Reaction notes

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