Diosgenin → Tigogenin

Participants

Reaction Steps

This Δ4, 3-keto steroidal sapogenin, for example diosgenone, is itself preferably prepared by an oxidation of the corresponding Δ5, 3-hydroxy steroidal sapogenin, for example diosgenin, to afford the αβ-unsaturated ketone. It will be noted that the direct reduction of diosgenin using palladium on carbon as a catalyst gives predominantly the 5α-product, tigogenin.

Provenance & Evidence