反应详情

Methyl 5-oxo-1-phenylprolinate (0.054 g, 0.25 mmol) was combined with 2M aqueous sodium hydroxide (0.160 ml, 0.32 mmol) in methanol (1 ml) and stirred overnight at room temperature. The solvent was then evaporated and the residue taken up in ethyl acetate and washed with 2M aqueous hydrogen chloride. The aqueous layer was separated and washed twice more with ethyl acetate and then the combined ethyl acetate layers were dried using a phase separator and evaporated to give 5-oxo-1-phenyl-proline (0.047 g) as a clear oil.

1. customThe solvent was then evaporated
2. washwashed with 2M aqueous hydrogen chloride
3. customThe aqueous layer was separated
4. washwashed twice more with ethyl acetate
5. dry with materialthe combined ethyl acetate layers were dried
6. customevaporated