化工社化工社 化学情報印刷レポート · 研究参考用
2-Chloro-4-fluorobenzylamine → N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxoprolinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-4-fluorobenzylamine | HCID 139909 | — |
| 反応物 | (4-Fluoro-2-(trifluoromethyl)phenyl)methanamine | HCID 2734878 | — |
| 反応物 | L-Proline, 1-ethyl-5-oxo- | HCID 18605196 | — |
| 反応物 | (2S)-1-methyl-5-oxopyrrolidine-2-carboxylic acid | HCID 18649403 | — |
| 反応物 | N-[(2-chloro-4-fluorophenyl)methyl]-1-ethyl-5-oxoprolinamide | HCID 49864911 | — |
| 生成物 | N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxoprolinamide | HCID 67458706 | — |
反応手順
N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxoprolinamide was prepared in a manner analogous to that described above for the synthesis of N-[(2-chloro-4-fluorophenyl)methyl]-1-ethyl-5-oxoprolinamide (Example 70) but 1-methyl-5-oxoproline (prepared as describe below) was substituted for 1-ethyl-5-oxoproline and {[4-fluoro-2-(trifluoromethyl)phenyl]methyl}amine was substituted for 2-chloro-4-fluorobenzylamine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07718693B2 |
| 出典データセット | uspto-grants-2010_05 |
| ORD ID | ord-ef671c41249e47279a1622cd1c4b4945 |
| 出典メモ | uspto-grants-2010_05 |