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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2238530Generated: October 25, 2026

Benzaldehyde → (S)-1-Benzyl-5-carboxy-2-pyrrolidinone

https://huagongshe.com/reaction/2238530

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzaldehydeHCID 240—
ReactantN-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1-(2,2-dimethylpropyl)-5-oxoprolinamideHCID 67460075—
Product(S)-1-Benzyl-5-carboxy-2-pyrrolidinoneHCID 10900113—

Reaction Steps

5-oxo-1-(phenylmethyl)proline was prepared in an analogous manner to that described above for the synthesis of 1-(2,2-dimethylpropyl)-5-oxoproline (example 100) but using benzaldehyde in the place of trimethylacetaldehyde.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07718693B2
Source datasetuspto-grants-2010_05
ORD IDord-f6711f67d0464220ab70c20bdb517b70
Source noteuspto-grants-2010_05