HCID 86617541, compound → HCID 67460678, compound

Participants

Reaction Conditions

Reaction Steps

1-(1,1-Dimethylethyl) 5-ethyl 3-methylglutamate (1.1 g, 4.5 mmol) was left to stand, attached to a high vacuum line, overnight and then over a weekend. Starting material was still evident at this stage so toluene (30 ml) was added and the resulting mixture was heated at 110° C. overnight. Evaporation gave 1,1-dimethylethyl 3-methyl-5-oxoprolinate (0.79 g) which was used in the next step without further purification.

Provenance & Evidence