2-Chloro-3-(trifluoromethyl)benzylamine → N-{[2-Chloro-3-(trifluoromethyl)phenyl]methyl}-1-ethyl-4,4-dimethyl-5-oxoprolinamide

HRID 2238561Notes

Reaction equation

HRID 2238561 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](F)[CH:5]=[CH:4][C:3]=1[CH2:9][NH:10][C:11](=[O:22])[C@@H:12]1[CH2:16][C:15]([CH3:18])([CH3:17])[C:14](=[O:19])[N:13]1[CH2:20][CH3:21].ClC1C([C:30]([F:33])([F:32])[F:31])=CC=CC=1CN>>[Cl:1][C:2]1[C:7]([C:30]([F:33])([F:32])[F:31])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][NH:10][C:11](=[O:22])[C@@H:12]1[CH2:16][C:15]([CH3:18])([CH3:17])[C:14](=[O:19])[N:13]1[CH2:20][CH3:21]

Participants

3

Reactant 2

HCID 52242072-Chloro-3-(trifluoromethyl)benzylamineHCID 67461683N-[(2-chloro-4-fluorophenyl)methyl]-1-ethyl-4,4-dimethyl-5-oxoprolinamide

Product 1

HCID 67460789N-{[2-Chloro-3-(trifluoromethyl)phenyl]methyl}-1-ethyl-4,4-dimethyl-5-oxoprolinamide

Procedure

N-{[2-Chloro-3-(trifluoromethyl)phenyl]methyl}-1-ethyl-4,4-dimethyl-5-oxoprolinamide was prepared in a manner analogous to that described above for the synthesis of N-[(2-chloro-4-fluorophenyl)methyl]-1-ethyl-4,4-dimethyl-5-oxoprolinamide (E130) but using {[2-chloro-3-(trifluoromethyl)phenyl]methyl}amine in the place of [(2-chloro-4-fluorophenyl)methyl]amine.

Sources & evidence

ORD record
ord-7a17b4c472f84842a27808ac6813f45c
Source dataset
uspto-grants-2010_05
Patent number
US07718693B2

Reaction notes

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