(2-Chloro-3,4-difluorophenyl)methanamine hydrochloride → N-[(2-chloro-3,4-difluorophenyl)methyl]-1-ethyl-4,4-dimethyl-5-oxoprolinamide

HRID 2238562Notes

Reaction equation

HRID 2238562 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][NH:10][C:11](=[O:22])[C@@H:12]1[CH2:16][C:15]([CH3:18])([CH3:17])[C:14](=[O:19])[N:13]1[CH2:20][CH3:21].Cl.ClC1C([F:31])=C(F)C=CC=1CN>>[Cl:1][C:2]1[C:7]([F:31])=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][NH:10][C:11](=[O:22])[C@@H:12]1[CH2:16][C:15]([CH3:17])([CH3:18])[C:14](=[O:19])[N:13]1[CH2:20][CH3:21]

Participants

3

Reactant 2

HCID 67103566(2-Chloro-3,4-difluorophenyl)methanamine hydrochlorideHCID 67461683N-[(2-chloro-4-fluorophenyl)methyl]-1-ethyl-4,4-dimethyl-5-oxoprolinamide

Product 1

HCID 67461981N-[(2-chloro-3,4-difluorophenyl)methyl]-1-ethyl-4,4-dimethyl-5-oxoprolinamide

Procedure

N-[(2-chloro-3,4-difluorophenyl)methyl]-1-ethyl-4,4-dimethyl-5-oxoprolinamide was prepared in a manner analogous to that described above for the synthesis of N-[(2-chloro-4-fluorophenyl)methyl]-1-ethyl-4,4-dimethyl-5-oxoprolinamide (E130) but using [(2-chloro-3,4-difluorophenyl)methyl]amine hydrochloride (prepared as described above for Example 36) in the place of [(2-chloro-4-fluorophenyl)methyl]amine.

Sources & evidence

ORD record
ord-eabf514edfee4aa187bec4ee6b3c3097
Source dataset
uspto-grants-2010_05
Patent number
US07718693B2

Reaction notes

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