Ethanol → HCID 23650677, compound

Participants

Reaction Steps

A mixture of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one hydrate (4.73 g, 3.25 mmol) and ethanol (small amount) was concentrated under reduced pressure, followed by adding ethyl acetate (small amount) to the residue before further concentration under reduced pressure. A 4N—HCl/ethyl acetate solution (3.9 mL, 15.6 mmol) was added to an ethyl acetate (80 mL) suspension containing the resultant residue, which was then stirred at room temperature for 3.5 hours. The precipitated solid was collected by filtration, washed with ethyl acetate (small amount), and then dried under reduced pressure to provide 4.64 g of the title compound as pale yellow crystals. (It was identified by Karl Fischer method that the crystal had a water content of 1.6%).

Provenance & Evidence