Acetone → HCID 23650059, compound

Participants

Reaction Conditions

Reaction Steps

A benzenesulfonic acid aqueous solution (1 mL, containing 2.02 mmol benzenesulfonic acid) was added to a mixture of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one (506 mg, 1.40 mmol) and acetone (5 mL), which was then heated to reflux in an oil bath for complete dissolution. Isopropanol (20 mL) was added to the mixture, which was then stirred at 60° C. for 40 minutes and subsequently allowed to stand for 13 hours in an oil bath, the heating of which was stopped. This mixture was then allowed to stand at 5° C. for 2 hours followed by collecting the precipitated solid by filtration. The resultant precipitate was dried with aeration at 60° C. for 3 hours to provide 442 mg of the title compound as pale yellow crystals.

Provenance & Evidence