Acetone → HCID 23650202, compound

Participants

Reaction Conditions

Reaction Steps

A p-toluenesulfonic acid aqueous solution (1.25 mL, containing 1.97 mmol p-toluenesulfonic acid) and isopropanol (30 mL) were added to a mixture of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one (532 mg, 1.47 mmol) and acetone (5 mL), which was then stirred at 80° C. (in an oil bath). Purified water (2.25 mL) was added to the mixture before filtration. The filtrate was again heated to 80° C. and then allowed to stand for 13 hours in an oil bath, the heating of which was stopped. This mixture was then allowed to stand at 5° C. for 5 hours, followed by collecting the precipitated solid by filtration. The obtained precipitate was dried with aeration at 60° C. for about 3 hours to provide 483 mg of the title compound as pale yellow crystals.

Provenance & Evidence