Succinic Acid → HCID 23650204, compound

HRID 2238577Notes

Reaction equation

HRID 2238577 reaction equation
C(#N)C.O.[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]1[C:14](=[O:31])[N:15]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:16]=[C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[CH:18]=1)#[N:6].[C:32]([OH:39])(=[O:38])[CH2:33][CH2:34][C:35]([OH:37])=[O:36]>CO>[C:32]([OH:39])(=[O:38])[CH2:33][CH2:34][C:35]([OH:37])=[O:36].[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]1[C:14](=[O:31])[N:15]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:16]=[C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[CH:18]=1)#[N:6]

Participants

5

Reactant 3

HCID 1110Succinic AcidHCID 6342AcetonitrileHCID 68419241HCID 68419241, compound

Product 1

HCID 23650204HCID 23650204, compoundYield 91.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Acetonitrile (5 mL) was added to 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one hydrate (255.2 mg, 0.70 mmol), and completely resolved under reflux by using oil bath. Then, methanol solution of succinic acid (2 mL, containing 0.77 mmol of succinic acid) was added, the heating of the oil bath was stopped, brought out from the oil bath, and subsequently allowed to stand at room temperature. The mixture returning to the room temperature was transferred to a weighing bottle and allowed to stand for about 15 hours. The solid precipitated was dried under reduced pressure at 60° C. for about 4 hours to provide 299.03 mg of the title compound as slightly yellowish white crystals.

Workup

  1. temperatureunder reflux
  2. temperaturethe heating of the oil bath
  3. customto stand at room temperature
  4. customreturning to the room temperature
  5. customThe solid precipitated
  6. customwas dried under reduced pressure at 60° C. for about 4 hours

Sources & evidence

ORD record
ord-c03e5de325ff424e9979e3a6513b2991
Source dataset
uspto-grants-2010_05
Patent number
US07718807B2

Reaction notes

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