反应详情

To a solution of 7-fluorochroman-4-ol (1.80 g, 10.7 mmol, STEP 1) and pyridine (0.35 mL) in diethyl ether (14 mL) was added thionyl chloride (3.9 mL, 53.5 mmol) at 0° C. The reaction mixture was stirred at the same temperature for 3 hours, and evaporated to remove excess thionyl chloride. The residue was quenched with water, and extracted with ethyl acetate. The extract was washed with brine, dried over magnesium sulfate, and concentrated in vacuum to afford the title compound as a pale brown solid (2.0 g, quant.):

1. customevaporated
2. customto remove excess thionyl chloride
3. customThe residue was quenched with water
4. extractionextracted with ethyl acetate
5. washThe extract was washed with brine
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated in vacuum