HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxy-N,N,1,2-tetramethyl-1H-benzimidazole-6-carboxamide → 4-[(5-Fluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-N,N,1,2-tetramethyl-1H-benzimidazole-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxy-N,N,1,2-tetramethyl-1H-benzimidazole-6-carboxamide | HCID 53471016 | — |
| Reactant | 4-Chloro-5-fluorochromane | HCID 68687658 | — |
| Product | 4-[(5-Fluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-N,N,1,2-tetramethyl-1H-benzimidazole-6-carboxamide | HCID 59303889 | 35% |
Reaction Steps
The title compound was prepared as a pale brown solid in 35% yield (69 mg) from 4-hydroxy-N,N,1,2-tetramethyl-1H-benzimidazole-6-carboxamide (120 mg, 0.51 mmol, WO 2004054984) and 4-chloro-5-fluorochromane (100 mg, 0.54 mmol, STEP 2) by the same manner in STEP 1 of Example 1:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07718809B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-3e316f7951f141829150fffe8b4ac511 |
| Source note | uspto-grants-2010_05 |