反应详情

The title compound was prepared as a white solid in 38% yield (35 mg) from 4-(3,4-dihydro-2H-chromen-4-yloxy)-1,2-dimethyl-1H-benzimidazole-6-carboxylic acid (70 mg, 0.21 mmol, STEP 2 in Example 11) and 1-acetylpiperazine (53 mg, 0.42 mmol) by the same manner in STEP 3 in Example 11: 1H NMR (CDCl3) δ: 7.31-7.23 (m, 2H), 7.21 (s, 1H), 6.89-6.77 (m, 3H), 6.50-6.00 (m, 1H), 4.50-4.40 (m, 1H), 4.27-4.32 (m, 1H), 3.75 (s, 3H), 3.80-3.36 (m, 8H), 2.64 (s, 3H), 2.40-2.19 (m, 2H), 2.13 (s, 3H) ppm;