HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine hydrochloride → 4-[(5,7-Difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-N,1,2-trimethyl-1H-benzimidazole-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine hydrochloride | HCID 6364545 | — |
| Reactant | 4-[(5,7-Difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-1,2-dimethyl-1H-benzimidazole-6-carboxylic acid | HCID 68690132 | — |
| Product | 4-[(5,7-Difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-N,1,2-trimethyl-1H-benzimidazole-6-carboxamide | HCID 59303892 | 96% |
Reaction Steps
The title compound was prepared as a colorless amorphous in 96% yield (0.99 g) from 4-[(5,7-difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-1,2-dimethyl-1H-benzimidazole-6-carboxylic acid (1.0 g, 2.7 mmol, STEP 2) and methanamine hydrochloride (0.54 g, 8.0 mmol) by the same manner in STEP 3 of Example 11.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07718809B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-230437024cfc453cb79572b8ee27b410 |
| Source note | uspto-grants-2010_05 |