反应详情

The title compound was prepared as a colorless amorphous in 80% yield (1.4 g) from 4-[(5,7-difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-1,2-dimethyl-1H-benzimidazole-6-carboxylic acid (1.6 g, 4.2 mmol, STEP 2 of Example 19) and azetidine hydrochloride (0.79 g, 8.4 mmol) by the same manner in STEP 3 of Example 11.