HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-methylazetidin-3-ol Hydrochloride → 1-({4-[(5,7-Difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-1,2-dimethyl-1H-benzimidazol-6-yl}carbonyl)-3-methylazetidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-methylazetidin-3-ol Hydrochloride | HCID 11542781 | — |
| Reactant | 4-[(5,7-Difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-1,2-dimethyl-1H-benzimidazole-6-carboxylic acid | HCID 68690132 | — |
| Product | 1-({4-[(5,7-Difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-1,2-dimethyl-1H-benzimidazol-6-yl}carbonyl)-3-methylazetidin-3-ol | HCID 59303885 | 76% |
Reaction Steps
The title compound was prepared as a colorless amorphous in 76% yield (71 mg) from 4-[(5,7-difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-1,2-dimethyl-1H-benzimidazole-6-carboxylic acid (80 mg, 0.21 mmol, STEP 2 of Example 21) and 3-methylazetidin-3-ol hydrochloride (crude 135 mg, STEP 1) by the same manner in STEP 3 of Example 11.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07718809B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-a6dab85fd4f1464abfe62a3c9191d15d |
| Source note | uspto-grants-2010_05 |