反应详情

To a stirred solution consisting of carbobenzyloxy-D-alanine (10.0 g) and N-aminopyrrole (3.68 g) in dry DCM (224 ml) was added DCC (9.71 g) at 0° C. under nitrogen. The cooling bath was removed after ten minutes and the reaction mixture was allowed to stir at room temperature for 24 hours. The suspension was filtered and the DCU filter cake was washed with hot ethyl acetate. Concentration of the filtrate gave the crude product. Recrystallization from EtOAc/hexane afforded 11.69 g of the desired product as a solid, m.p. 172°-174° C.

1. customThe cooling bath was removed after ten minutes
2. filtrationThe suspension was filtered
3. filtrationthe DCU filter cake
4. washwas washed with hot ethyl acetate
5. customConcentration of the filtrate gave the crude product
6. customRecrystallization from EtOAc/hexane