反应详情

To a suspension of PCC (3.69 g, 17.10 mmol) in methylene chloride (20 ml), a solution of 3-(2-phenylethyl)-2,3-dihydro-1-benzofuran-5-yl-methanol (3.32 g, 13.16 mmol) in methylene chloride (100 ml) was added at room temperature. After stirring for 12 h, diethyl ether (300 ml) was added and the black solid precipitated was filtered and washed with diethyl ether several times. The filtrate was concentrated under vacuum and the residue was purified by flash chromatography on silica gel (petroleum ether/ethyl acetate=95/5-9/1) affording 0.202 g of the title compound (67% yield).

1. customthe black solid precipitated
2. filtrationwas filtered
3. washwashed with diethyl ether several times
4. concentrationThe filtrate was concentrated under vacuum
5. customthe residue was purified by flash chromatography on silica gel (petroleum ether/ethyl acetate=95/5-9/1)