2-Amino-3-methylpyridine → HCID 4062357, compound

Participants

Reaction Steps

2 g of 2-amino-3-picoline was dissolved in a mixture solvent of 10 mL of tetrahydrofuran and 5 mL of diethyl ether, 4.4 mL of 3-chloroacetyl acetone was added, and heated overnight under reflux. The reaction mixture was cooled back to room temperature, diluted with ethyl acetate, and then washed with water and with saturated brine in the subsequent order. After drying the organic layer over anhydrous magnesium sulfate, the insolubles were filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was dissolved in a small amount of chloroform and solidified by adding hexane, to obtain 664 mg of 1-(2,8-dimethylimidazo[1,2-a]pyridin-3-yl)ethanone [38-1] as a light grey solid.

Provenance & Evidence