Water → HCID 68684710, compound

Participants

Reaction Steps

5 g of the 1-(4-{[t-butyl(diphenyl)silyl]oxy}phenyl)-1-ethanone [79-1] was dissolved in a mixture solvent of 50 mL of methanol and 30 mL of tetrahydrofuran, 606 mg of sodium borohydride was added thereto, and stirred at room temperature for 3 hours. The reaction mixture was added with 30 mL of water, and concentrated under reduced pressure. The residue was added with 150 mL of ethyl acetate, washed with water and saturated brine in the subsequent order, and the obtained organic layer was dried over anhydrous magnesium sulfate. The insolubles were filtered, the filtrate was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography, to obtain 5.02 g of 1-(4-{[t-butyl(diphenyl)silyl]oxy}phenyl)-1-ethanol [79-2] as a colorless oily product.

Provenance & Evidence