HCID 68686560, compound → HCID 68688595, compound

Participants

Reaction Steps

83 mg of the 4-[8-(difluoromethyl)imidazo[1,2-a]pyridin-3-yl]-2-{[(1S)-1-(4-nitrophenyl)ethyl]amino}pyrimidine-5-carbonitrile [103-1] was dissolved in a mixture solvent of 2 mL of ethanol and 3 mL of tetrahydrofuran, then 40 mg of 10% palladiumcarbon catalyst was added, and stirred overnight at room temperature in a hydrogen atmosphere. The insolubles were filtered through celite and the filtrate was concentrated under reduced pressure to obtain a residue. The residue was purified by preparative thin-layer chromatography, and 14 mg of 2-{[(1S)-1-(4-aminophenyl)ethyl]amino}-4-[8-(difluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-5-carbonitrile [103-2] was obtained as pale yellow amorphous.

Provenance & Evidence