Cesium carbonate → HCID 131728128, compound

Participants

Reaction Steps

The mixture of 100 mg of the t-butyl[(1S)-1-(4-bromophenyl)ethyl]carbamate [106-1], 73 mg of 2,2,2-trifluoro-1-piperazin-1-yl-ethanone (synthesized according to a method disclosed in page 7357-7360 in Tetrahedron Lett. 1995, 41), 3.7 mg of palladium acetate, 10.7 mg of 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl, 217 mg of cesium carbonate, and 3 mL of toluene, was stirred overnight at 100° C. After cooling the reaction mixture back to room temperature, the insolubles were filtered through celite, the filtrate was concentrated under reduced pressure, and the thus obtained residue was purified by preparative thin-layer chromatography, to obtain 73 mg of t-butyl((1S)-1-{4-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}ethyl)carbamate [110-1] as a white solid.

Provenance & Evidence