反应详情

Compound 32 (391 mg, 1.00 mmol) was dissolved in 1,4-dioxane (4 mL), and ethanolamine (0.300 mL, 5.00 mmol) was added thereto, followed by stirring overnight under heating and reflux. The reaction mixture was concentrated under reduced pressure, and a saturated aqueous solution of sodium chloride and chloroform were added to the resulting residue, and the precipitated solid was collected by filtration to afford the entitled Compound 33 (244 mg, 59%).

1. temperatureunder heating
2. temperaturereflux
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. additiona saturated aqueous solution of sodium chloride and chloroform were added to the resulting residue
5. filtrationthe precipitated solid was collected by filtration