5-Formyl-2-methoxyphenylboronic acid → 3-(4-Ethyl-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-4-methoxy-benzaldehyde

HRID 2239243Notes

Reaction equation

HRID 2239243 reaction equation
[CH2:1]([N:3]1[C:8]2[CH:9]=[C:10]([C:14]3[CH:15]=[C:16]([CH:19]=[CH:20][C:21]=3[O:22][C:23](F)(F)F)[CH:17]=[O:18])[C:11]([CH3:13])=[CH:12][C:7]=2[O:6][C:5]([CH3:28])([CH3:27])[C:4]1=[O:29])[CH3:2].BrC1C(C)=CC2OC(C)(C)C(=O)N(CC)C=2C=1.COC1C=CC(C=O)=CC=1B(O)O>>[CH2:1]([N:3]1[C:8]2[CH:9]=[C:10]([C:14]3[CH:15]=[C:16]([CH:19]=[CH:20][C:21]=3[O:22][CH3:23])[CH:17]=[O:18])[C:11]([CH3:13])=[CH:12][C:7]=2[O:6][C:5]([CH3:28])([CH3:27])[C:4]1=[O:29])[CH3:2]

Participants

4

Reactant 3

HCID 27343675-Formyl-2-methoxyphenylboronic acidHCID 685847416-Bromo-4-ethyl-2,2,7-trimethyl-4H-benzo[1,4]oxazin-3-oneHCID 866116753-(4-Ethyl-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-4-trifluoromethoxy-benzaldehyde

Product 1

HCID 866116763-(4-Ethyl-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-4-methoxy-benzaldehyde

Procedure

This was prepared using a procedure similar to that described to make Compound 1D, except using Compound 1C and 2-methoxy-5-formylphenylboronic acid in Step D. MS (electrospray): mass calculated for C21H23NO4, 353.16; m/z found 354.1 [M+H]+.

Workup

  1. customThis was prepared

Sources & evidence

ORD record
ord-4e734b3adbf74ca79b3667ceec9ede31
Source dataset
uspto-grants-2010_05
Patent number
US07723326B2

Reaction notes

Loading…