反应详情

Compound 16A (6.33 mmol, 1.5 g) was dissolved in 75 mL of CH2Cl2 and then MnO2 (75 mmol, 6.55 g) was added. The black suspension was stirred overnight at r.t. and then filtered through a pad of celite. The celite pad was washed with CH2Cl2 and the combined filtrates were dried over Na2SO4. The solvent was filtered and the solvent was removed in vacuo to yield (2-formyl-4-methyl-phenyl)-carbamic acid tert-butyl ester as yellow thick oil (1.45 g). MS (electrospray): mass calculated for C13H17NO3, 235.12; m/z found 236, [M+H]+.

1. filtrationfiltered through a pad of celite
2. washThe celite pad was washed with CH2Cl2
3. dry with materialthe combined filtrates were dried over Na2SO4
4. filtrationThe solvent was filtered
5. customthe solvent was removed in vacuo