(6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-thioacetic acid S-pyridin-2-yl ester → 1-(6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-heptan-2-one

Participants

Reaction Steps

Prepared from (6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-thioacetic acid S-pyridin-2-yl ester 1c and pentylmagnesium bromide using a similar procedure described above. 1H NMR (400 MHz, CDCl3) δ 0.81 (t, 3H), 1.17 (m, 6H), 1.51 (m, 2H), 2.28 (s, 3H), 2.37 (s, 3), 4.04 (s, 2H), 7.00 (d, J=8.4 Hz, 1H), 7.23 (d, J=7.3 Hz, 2H), 7.55 (m, 4H). Mass spectrum m/e 335 (M+).

Provenance & Evidence