反应详情

To a stirred suspension consisting of 2-(2-phenyl-1H-pyrrol-1-yl)-1H-isoindol-1,3(2H)dione (7.2 g) in abs. ethanol (150 ml) was added hydrazine (3.9 ml) at room temperature. The reaction mixture was warmed to reflux for 2 hours and allowed to cool to room temperature overnight. The solid by-product was filtered and washed with ether. The combined filtrates were concentrated in vacuo to give an oil which solidified on standing. Recrystallization from ether afforded 3.9 g of the product as a solid, m.p. 80°-82° C.

1. temperatureThe reaction mixture was warmed
2. temperatureto reflux for 2 hours
3. filtrationThe solid by-product was filtered
4. washwashed with ether
5. concentrationThe combined filtrates were concentrated in vacuo
6. customto give an oil which
7. customRecrystallization from ether