Methyl 4-(Benzyloxy)-1-Boc-2-methyl-1H-benzo[d]imidazole-6-carboxylate → Methyl 1-Boc-4-hydroxy-2-methyl-1H-benzo[d]imidazole-6-carboxylate

Participants

Reaction Steps

A mixture of 1-(1,1-dimethylethyl) 6-methyl 2-methyl-4-[(phenylmethyl)oxy]-1H-benzimidazole-1,6-dicarboxylate (12.1 g, crude, STEP 2) and 20% palladium hydroxide (6.0 g) in tetrahydrofuran (250 mL) was stirred under hydrogen gas for 2 hours. The resulted mixture was filtered through a pad of Celite, and the filtrate was concentrated in vacuum. The residue was washed with hexane/diethyl ether (10:1) to give the title compound as a white solid (3.02 g, 28% for 3 steps).

Provenance & Evidence