HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Methylamino)ethanol → 4-[(5,7-Difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-N-(2-hydroxyethyl)-N,2-dimethyl-1H-benzimidazole-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Methylamino)ethanol | HCID 8016 | — |
| Reactant | 7-[(5,7-Difluorochroman-4-yl)oxy]-2-methyl-1H-benzo[d]imidazole-5-carboxylic Acid | HCID 68574559 | — |
| Product | 4-[(5,7-Difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-N-(2-hydroxyethyl)-N,2-dimethyl-1H-benzimidazole-6-carboxamide | HCID 58900199 | 40% |
Reaction Steps
The title compound was prepared as a white solid (50 mg, 40% yield for 3 steps) from 4-[(5,7-difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-2-methyl-1H-benzimidazole-6-carboxylic acid (100 mg, crude, STEP 4 in Example 4) and 2-(methylamino)ethanol (63 mg, 0.83 mmol) by the same manner in STEP 5 of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723321B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-377df1b9fa4949f8aed5bc5dce9dcffd |
| Source note | uspto-grants-2010_05 |