HCID 64853602, compound → HCID 55275761, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(2-fluoro-5-methylphenoxy)propanoic acid (2.45 g, 12.4 mmol, STEP 1-1) in polyphosphoric acid (35 g) was stirred at 100° C. for 2 hours. After cooling to room temperature, the mixture was diluted with water (150 mL), and extracted with ethyl acetate (60 mL×2). The organic layers were combined, washed with brine, dried over magnesium sulfate, and concentrated in vacuum to afford the title compound as a white solid (2.30 g, quant.).

Provenance & Evidence