HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azetidine hydrochloride → (-)-6-(Azetidin-1-ylcarbonyl)-4-[(5,7-difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-2-methyl-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azetidine hydrochloride | HCID 12308726 | — |
| Reactant | 7-[(5,7-Difluorochroman-4-yl)oxy]-2-methyl-1H-benzo[d]imidazole-5-carboxylic Acid | HCID 68574559 | — |
| Product | (-)-6-(Azetidin-1-ylcarbonyl)-4-[(5,7-difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-2-methyl-1H-benzimidazole | HCID 58900200 | — |
Reaction Steps
The title compound was prepared as a white solid (132 mg, 79%) from (−)-4-[(5,7-difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-2-methyl-1H-benzimidazole-6-carboxylic acid (150 mg, STEP 1) and azetidine hydrochloride (117 mg, 1.25 mmol) by the same manner in STEP 5 of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723321B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-9003eb1eaa6c45979eca0c48ee40088b |
| Source note | uspto-grants-2010_05 |