[3-(2-morpholinoethoxy)phenyl]methylamine → HCID 24785532, compound

Participants

Reaction Steps

5-(4-Chlorophenyl)-3-(dimethylamino-methyleneamino)-thiophene-2-carboxylic acid methyl ester (0.164 g, 0.508 mmol), 3-(2-morpholin-4-yl-ethoxy)-benzylamine (0.100 g, 0.423 mmol) and MeOH (1.5 mL) were heated by MW at 120° C. for 15 minutes. The reaction mixture was allowed to cool to r.t., the precipitate filtered, washed with MeOH, and dried in vacuo to give the product. Yield: 0.110 g (45%). 1H NMR (400 MHz, CDCl3) δ 8.11 (s, 1H), 7.63 (d, 2H, J=8.42 Hz), 7.45 (s, 1H), 7.41 (d, 2H, J=8.42 Hz), 7.25 (m, 1H), 6.81-6.94 (m, 3H), 5.17 (s, 2H), 4.06 (t, 2H, J=6.12 Hz), 3.70 (t, 4H, J=4.68 Hz), 2.75 (t, 2H, J=5.58 Hz), 2.53 (t, 4H, J=4.51 Hz). MS (ESI+) 481.92 (M+1H+).

Provenance & Evidence