Methyl 5-(4-chlorophenyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylate → HCID 24785804, compound

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5-(4-Chloro-phenyl)-3-(dimethylamino-methyleneamino)-thiophene-2-carboxylic acid methyl ester (0.165 g, 0.51 mmol) and 1-{3-[(1-methylpiperidin-4-yl)methoxy]phenyl}-methanamine (0.100 g, 0.43 mmol) in MeOH (2 mL) was heated by microwave at 120° C. in 20 minutes, cooled, the formed precipitate filtered off and washed with MeOH to give the title compound as a white solid. Yield: 0.075 g (31%). 1H NMR (400 MHz, CDCl3) δ 8.07 (s, 1H), 7.58-7.63 (m, 2H), 7.45 (s, 1H), 7.38-7.43 (m, 2H), 7.22 (m, 1H), 6.79-6.91 (m, 3H), 5.17 (s, 2H), 3.76 (d, 2H, J=6.4 Hz), 2.82-2.89 (m, 2H), 2.25 (s, 3H), 1.87-1.96 (m, 2H), 1.76-1.83 (m, 2H), 1.68-1.76 (m, 1H), 1.32-1.44 (m, 2H).

Provenance & Evidence