HCID 21959661, compound → HCID 21959563, compound

Participants

Reaction Steps

2-[(1-Methylpiperidin-4-yl)oxy]isonicotinonitrile (0.250 g, 1.51 mmol, from step a above) was dissolved in 10 mL of ammonia saturated MeOH and 0.200 g Raney Nickel was added. The mixture was hydrogenated at 5 atm overnight. The mixture was filtered and evaporated to give 0.242 g (95%) of crude product which was used in the following step. 1H NMR (300 MHz, CD3OD) δ 8.01 (d, 1H), 6.89 (d, 1H), 6.76 (bs, 1H), 5.00 (m, 1H), 3.77 (bs, 2H), 2.73 (m, 2H), 2.37 (m, 2H), 2.30 (s, 3H), 2.03 (m, 2H), 1.81 (m, 2H).

Provenance & Evidence