HCID 68705096, compound → HCID 24786071, compound

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Reaction Steps

The title compound was synthesized according to Example 13c from methyl 5-(4-chlorophenyl)-3-{[(1E)-(dimethylamino)methylene]amino}thiophene-2-carboxylate (0.352 g, 1.09 mmol) and 1-{3-[(1-methylpyrrolidin-3-yl)methoxy]phenyl}methanamine (0.200 g, 0.91 mmol) in MeOH (2 mL) to give the title compound. Yield: 0.225 g (44%). 1H NMR (400 MHz, CDCl3) δ 8.08 (s, 1H), 7.59-7.62 (m, 2H), 7.45 (s, 1H), 7.39-7.42 (m, 2H), 7.22-7.26 (m, 1H), 6.81-6.91 (m, 3H), 5.17 (s, 2H), 3.83 (d, 2H, J=6.9 Hz), 2.60-2.66 (m, 2H), 2.38-2.57 (m, 3H), 2.32 (s, 3H), 1.97-2.08 (m, 1H), 1.51-1.60 (m, 1H). MS (ESI+) 465.99 (M+1H+)

Provenance & Evidence