Dimethylamine → 4-Bromo-N,N-dimethylbenzenesulphonamide

Participants

Reaction Steps

In an analogous manner to General Procedure A, 4-Bromobenzene sulfonyl chloride (0.40 g, 1.56 mmol) and dimethylamine (10 mL, 33% in ethanol) were stirred together for 16 hours. 4-bromo-N,N-dimethylbenzenesulfonamide (0.11 g) was provided after purification. MS (ESI) m/z 264. HPLC purity 100.0% at 210-370 mn, 8.3 min.; the Xterra® RP18 column, 3.5μ, 150×4.6 mm column, 1.2 mL/min., 85/15-5/95 (ammonium formate buffer pH=3.5/ACN+MeOH) for 10 min., hold 4 min.

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