Cyclopropanemethanamine → 4-Bromo-N-(cyclopropylmethyl)-2-fluorobenzenesulfonamide

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Reaction Steps

According to general procedure C, 4-Bromo-2-fluoro-benzenesulfonyl chloride (0.40 g, 1.46 mmol) and cyclopropylmethylamine (0.31 mL, 3.65 mmol) were stirred together with dry dichloromethane (5 mL) for 16 hours. 4-bromo-N-(cyclopropylmethyl)-2-fluorobenzenesulfonamide (0.18 g, 40%) was provided after purification. MS (ESI) m/z 308. HPLC purity 97.7% at 210-370 nm, 10.7 min.; the Xterra® RP18 column, 3.5μ, 150×4.6 mm column, 1.2 mL/min., 85/15-5/95 (Ammonium Bicarb Buff. pH=9.5/ACN+MeOH) for 10 min., hold 4 min.

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