Isopropylamine → HCID 68483705, compound

HRID 2239496Notes

Reaction equation

HRID 2239496 reaction equation
[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([S:9](Cl)(=[O:11])=[O:10])=[C:4]([F:13])[CH:3]=1.[CH:14]([NH2:17])([CH3:16])[CH3:15]>ClCCl>[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([S:9]([NH:17][CH:14]([CH3:16])[CH3:15])(=[O:11])=[O:10])=[C:4]([F:13])[CH:3]=1

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 5745904-Bromo-2,5-difluorobenzenesulfonyl Chloride

Product 1

HCID 68483705HCID 68483705, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

According to general procedure C, 4-Bromo-2,5-difluorobenzenesulfonyl chloride (0.20 g, 0.68 mmol) and isopropylamine were stirred together in dichloromethane (1 mL) for 16 hours. The reaction afforded 4-bromo-2,5-difluoro-N-isopropylbenzenesulfonamide (0.16 g) after purification. HPLC purity 96.6% at 210-370 nm, 10.7 min.; the Xterra® RP18 column, 3.5μ, 150×4.6 mm column, 1.2 mL/min., 85/15-5/95 (ammonium formate buffer pH=3.5/ACN+MeOH) for 10 min., hold 4 min. HRMS: calcd for C9H10BrF2NO2S−H+, 311.95109; found (ESI-FTMS, [M−H]1−), 311.95114

Sources & evidence

ORD record
ord-0aaa2c1fcea940268130f02a139786ea
Source dataset
uspto-grants-2010_05
Patent number
US07723332B2

Reaction notes

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