HCID 67083935, compound → HCID 67083714, compound

Participants

Reaction Steps

A solution of 4-(2-fluoro-4-methylphenylamino)-7-methoxy-6-(1,2,3,6-tetrahydropyridin-4-yl)cinnoline-3-carboxamide (Example 52, 0.9 g, 2.21 mmol) in MeOH (44.2 ml) with a few drops of conc. HCl was passed through an H Cube apparatus using a 20 wt % Pd(OH)2/Carbon cartridge, at 10 bar. The solvent was removed under reduced pressure and the residue was purified with silica chromatography CH2Cl2/10% MeOH (1% NH4OH) to give 692 mg (77%) of a light yellow solid. 1H NMR: MeOD 7.61 (s, 1H), 7.37 (m, 1H), 7.23 (m, 1H), 7.12 (m, 2H), 4.09 (s, 3H), 3.38 (m, 2H), 3.22 (m, 1H), 3.12 (m, 2H), 2.43 (s, 3H), 1.90 (m, 2H), 1.36 (m, 2H); m/z 410.

Provenance & Evidence