Trifluoroacetic acid → HCID 67083935, compound

Participants

Reaction Steps

A solution of tert-butyl 4-(3-carbamoyl-4-(2-fluoro-4-methylphenylamino)-7-methoxycinnolin-6-yl)-5,6-dihydropyridine-1(2H)-carboxylate (Example 53, 1.5 g, 2.96 mmol) in CH2Cl2 (11.84 mL) and trifluoroacetic acid (11.84 mL, 153.68 mmol) was stirred for 16 hours, concentrated under reduced pressure, and the residue purified with silica chromatography CH2Cl2/5% MeOH (1% NH4OH) to give 960 mg (80%) product. m/z 408.

Provenance & Evidence