反应详情

A mixture of benzyl 4-(2-(tert-butyldimethylsilyloxy)ethyl)piperazine-1-carboxylate (Method 90, 2.1 g, 5.55 mmol) and Pd/C (0.059 g, 0.55 mmol) in methanol (30 mL) was stirred under H2 (g) for 24 hours. The reaction mixture was filtered through a pad of Celite and concentrated under reduced pressure to give 1.20 g, (88%) of a yellow oil. 1H NMR: CD3Cl 3.74 (t, 2H), 2.90 (m, 4H), 2.51 (m, 6H), 0.88 (s, 9H), 0.04 (s, 6H).

1. filtrationThe reaction mixture was filtered through a pad of Celite
2. concentrationconcentrated under reduced pressure