Isopropylamine → HCID 67242921, compound

HRID 2239723Notes

Reaction equation

Cl[C:2]1[C:3](=[O:18])[N:4]([CH:15]([CH3:17])[CH3:16])[S:5](=[O:14])(=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[CH:19]([NH2:22])([CH3:21])[CH3:20]>>[CH:15]([N:4]1[C:3](=[O:18])[C:2]([NH:22][CH:19]([CH3:21])[CH3:20])=[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[S:5]1(=[O:14])=[O:13])([CH3:17])[CH3:16]

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 672431604-Chloro-2-isopropyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide

Product 1

HCID 67242921HCID 67242921, compound

Procedure

The title compound was prepared from 4-chloro-2-isopropyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide and isopropylamine in a similar manner as described for Example 24. 1H NMR (500 MHz CDCl3): δ 7.56-7.51 (m, 2H), 7.48-7.43 (m, 3H), 5.14 (d, 1H), 4.42 (sept, 1H), 3.40-3.30 (m, 1H), 1.60 (d, 6H), 1.00 (d, 6H); 13C NMR (125 MHz CDCl3): δ 158.9, 134.6, 131.7, 129.9, 128.9, 125.5, 106.3, 47.8, 44.9, 23.0, 20.4; Mass Spectrum: M+H+ 309.

Sources & evidence

ORD record: ord-ba2e23df65e8435096a332b13262b7de
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07723333B2

Reaction notes

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