tert-Butyl [4-(2-aminoethyl)pyridin-2-yl]carbamate → HCID 67243361, compound

Participants

Reaction Steps

The title compound was prepared in two steps. tert-Butyl (4-{2-[(2-isopropyl-1,1-dioxido-3-oxo-5-phenyl-2,3-dihydroisothiazol-4-yl)amino]ethyl}pyridin-2-yl)carbamate was prepared from 4-chloro-2-isopropyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide and tert-butyl [4-(2-aminoethyl)pyridin-2-yl]carbamate in a similar manner as described for Example 118. Deprotection of tert-butyl (4-{2-[(2-isopropyl-1,1-dioxido-3-oxo-5-phenyl-2,3-dihydroisothiazol-4-yl)amino]ethyl}pyridin-2-yl)carbamate in a similar manner as described for 1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]azetidin-3-amine gave the title compound.

Provenance & Evidence