HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2239749Generated: October 28, 2026
Acetyl chloride → (S)-5-aminopiperidin-2-one hydrochloride
https://huagongshe.com/reaction/2239749
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Reactant | (S)-tert-butyl 6-oxopiperidin-3-ylcarbamate | HCID 15466433 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (S)-5-aminopiperidin-2-one hydrochloride | HCID 42614518 | 99% |
Reaction Steps
N-((3S)-6-Oxo(3-piperidyl))(tert-butoxy)carboxamide (3.9 mmol, 0.83 g) were dissolved in ethanol (10 mL) and cooled to 0° C. Acetyl chloride (2 mL) was added and the reaction was allowed to reach room temperature. The reaction was stirred for 1 hour after which the solvent was removed in vacuo to yield the title compound (725 mg, 99% yield) as the dihydrochloride salt. ES-MS: 115 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07723340B2 |
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| Source dataset | uspto-grants-2010_05 |
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| ORD ID | ord-378afabc157941deb50e0323369a44f3 |
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| Source note | uspto-grants-2010_05 |
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