Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | HCID 178496620 | HCID 178496620 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178496609 | HCID 178496609 | 126.6% |
Reaction Steps
trans-(tert-Butoxy)-N-(4-methoxycyclohexyl)carboxamide (642 mg, 2.80 mmol) was dissolved in ethanol (5 mL) and cooled to 0° C. Acetyl chloride (1.5 mL) was added and the reaction was allowed to reach room temperature and stirred overnight. Solvent was removed in vacuo to give the desired product (458 mg, quantitative yield) as a hydrochloride salt. ES-MS: 130 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07723340B2 |
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| Source dataset | uspto-grants-2010_05 |
|---|
| ORD ID | ord-529a2218bcd14d70867c9396aebac8aa |
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| Source note | uspto-grants-2010_05 |
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