反应详情

温度

110 °C

Chloroacetaldehyde (1.6 ml, 10 mmol, 50% in H2O) was added to a solution of crude 4-bromo-6-chloro-5-methylpyridazin-3-amine (0.5 g, 2 mmol) from 1b in EtOH (5 mL). The mixture was heated in a sealed vial at 110° C. for 2 h. Solvent was removed in vacuo and the resulting solid was suspended in acetone/Et2O (1/1, 5 mL), filtered, and then washed with Et2O to give 8-bromo-6-chloro-7-methylimidazo[1,2-b]pyridazine HCl salt (0.5 g, >90% pure).

1. customSolvent was removed in vacuo
2. filtrationfiltered
3. washwashed with Et2O