4-Ethoxyaniline → HCID 86611716, compound

Participants

Reaction Conditions

Reaction Steps

6-Hydroxy-7,8-dichloroimidazo[1,2-b]pyridazine (0.1 g, 0.5 mmol) from 1c was added to POCl3 (0.4 mL, 1.4 M) in a 1 dram vial. The mixture was heated to 120° C. for 2 days. Upon cooling CH2Cl2 was added and the mixture was poured onto ice water. The layers were separated and the aqueous layer was extracted with CH2Cl2 (15 mL). The organic layers were combined and washed with H2O (5 mL), followed by brine (5 mL). The solution was dried over Na2SO4 and concentrated in vacuo to give 6,7,8-trichloroimidazo[1,2-b]pyridazine as a tan solid (0.04 g, 37%).

Provenance & Evidence